High cumulative risks of cancer in patients with PTEN hamartoma tumour syndrome
Identifieur interne : 000484 ( Main/Exploration ); précédent : 000483; suivant : 000485High cumulative risks of cancer in patients with PTEN hamartoma tumour syndrome
Auteurs : Virginie Bubien [France] ; Françoise Bonnet [France] ; Veronique Brouste [France] ; Stéphanie Hoppe [France] ; Emmanuelle Barouk-Simonet [France] ; Albert David [France] ; Patrick Edery [France] ; Armand Bottani [Suisse] ; Valérie Layet [France] ; Olivier Caron [France] ; Brigitte Gilbert-Dussardier [France] ; Capucine Delnatte [France] ; Catherine Dugast [France] ; Jean-Pierre Fricker [France] ; Dominique Bonneau [France] ; Nicolas Sevenet [France] ; Michel Longy [France] ; Frédéric Caux [France] ; Marc Abramowicz ; Didier Bessis ; Eric Bieth ; Valérie Bonadonaon Bérard ; Jean-Marie Bonnetblanc ; Liliane Demange ; François Feillet ; Thierry Frebourg ; Sophie Giraud ; Irina Giurgea ; Delphine Heron ; Muriel Holder ; Hubert Journel ; Sophie Julia ; Maha Kacem ; Sophie Lejeune ; Frédéric Leprat ; Dominique Leroux ; Catherine Lok ; Alain Lortholary ; Stanislas Lyonnet ; Geneviève Margueritte ; Jacques Mauillon ; Juliette Mazereeuw-Hautier ; Sylvie Odent ; Clotilde Penet ; Anne Philippe ; Henri Plauchu ; Ghislaine Plessismenceau ; Emmanuel Plouvieron ; Marie-Aleth Richard ; Abdelkrim Saadi ; Jean-Christophe Saurin ; Julie Tinat ; Pierre Vabres ; Lionel Van Maldergemteil ; Philippe Vennin ; Pierre-Jean WeillerSource :
- Journal of Medical Genetics [ 0022-2593 ] ; 2013-04.
Abstract
Background PTEN hamartoma tumour syndrome (PHTS) encompasses several clinical syndromes with germline mutations in the PTEN tumour suppressor gene, including Cowden syndrome which is characterised by an increased risk of breast and thyroid cancers. Because PHTS is rare, data regarding cancer risks and genotype–phenotype correlations are limited. The objective of this study was to better define cancer risks in this syndrome with respect to the type and location of PTEN mutations. Methods 154 PHTS individuals with a deleterious germline PTEN mutation were recruited from the activity of the Institut Bergonié genetic laboratory. Detailed phenotypic information was obtained for 146 of them. Age and sex adjusted standardised incidence ratio (SIR) calculations, cumulative cancer risk estimations, and genotype–phenotype analyses were performed. Results Elevated SIRs were found mainly for female breast cancer (39.1, 95% CI 24.8 to 58.6), thyroid cancer in women (43.2, 95% CI 19.7 to 82.1) and in men (199.5, 95% CI 106.39 to 342.03), melanoma in women (28.3, 95% CI 7.6 to 35.4) and in men (39.4, 95% CI 10.6 to 100.9), and endometrial cancer (48.7, 95% CI 9.8 to 142.3). Cumulative cancer risks at age 70 were 85% (95% CI 70% to 95%) for any cancer, 77% (95% CI 59% to 91%) for female breast cancer, and 38% (95% CI 25% to 56%) for thyroid cancer. The risk of cancer was two times greater in women with PHTS than in men with PHTS (p<0.05). Conclusions This study shows a considerably high cumulative risk of cancer for patients with PHTS, mainly in women without clear genotype–phenotype correlation for this cancer risk. New recommendations for the management of PHTS patients are proposed.
Url:
DOI: 10.1136/jmedgenet-2012-101339
Affiliations:
- France, Suisse
- Aquitaine
- Angers, Bobigny, Bordeaux, Le Havre, Nantes, Poitiers, Rennes, Strasbourg
- Université de Bordeaux
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xml:lang="fr">France</country><wicri:regionArea>Inserm U 916 Institut Bergonié, Université de Bordeaux, Bordeaux</wicri:regionArea><placeName><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université de Bordeaux</orgName><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Aquitaine</region></placeName></affiliation></author><author><name sortKey="Brouste, Veronique" sort="Brouste, Veronique" uniqKey="Brouste V" first="Veronique" last="Brouste">Veronique Brouste</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Clinical and Epidemiological Research Unit, Institut Bergonié, Bordeaux</wicri:regionArea><placeName><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Hoppe, Stephanie" sort="Hoppe, Stephanie" uniqKey="Hoppe S" first="Stéphanie" last="Hoppe">Stéphanie Hoppe</name><affiliation wicri:level="1"><country 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type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Edery, Patrick" sort="Edery, Patrick" uniqKey="Edery P" first="Patrick" last="Edery">Patrick Edery</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Genetics, Hospices Civils de Lyon, Bron</wicri:regionArea><wicri:noRegion>Bron</wicri:noRegion><wicri:noRegion>Bron</wicri:noRegion></affiliation></author><author><name sortKey="Bottani, Armand" sort="Bottani, Armand" uniqKey="Bottani A" first="Armand" last="Bottani">Armand Bottani</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Medical Genetics Unit, Centre Hospitalier Universitaire de Genève, Geneve</wicri:regionArea><wicri:noRegion>Geneve</wicri:noRegion></affiliation></author><author><name sortKey="Layet, Valerie" sort="Layet, Valerie" uniqKey="Layet V" first="Valérie" last="Layet">Valérie Layet</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Medical Genetics Unit, Hôpital Jacques Monod, Le Havre</wicri:regionArea><placeName><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Caron, Olivier" sort="Caron, Olivier" uniqKey="Caron O" first="Olivier" last="Caron">Olivier Caron</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Cancer Genetics Unit, Institut Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Gilbert Dussardier, Brigitte" sort="Gilbert Dussardier, Brigitte" uniqKey="Gilbert Dussardier B" first="Brigitte" last="Gilbert-Dussardier">Brigitte Gilbert-Dussardier</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Medical Genetics Unit, Centre Hospitalier Universitaire de Poitiers, 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first="Jean-Pierre" last="Fricker">Jean-Pierre Fricker</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Cancer Genetics Unit, Centre Paul Strauss, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Bonneau, Dominique" sort="Bonneau, Dominique" uniqKey="Bonneau D" first="Dominique" last="Bonneau">Dominique Bonneau</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Medical Genetics Unit, Centre Hospitalier Universitaire d'Angers, Angers</wicri:regionArea><placeName><settlement type="city">Angers</settlement></placeName></affiliation></author><author><name sortKey="Sevenet, Nicolas" sort="Sevenet, Nicolas" uniqKey="Sevenet N" first="Nicolas" last="Sevenet">Nicolas Sevenet</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Cancer Genetics Unit, Institut Bergonié, 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916 Institut Bergonié, Université de Bordeaux, Bordeaux</wicri:regionArea><placeName><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université de Bordeaux</orgName><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Aquitaine</region></placeName></affiliation></author><author><name sortKey="Caux, Frederic" sort="Caux, Frederic" uniqKey="Caux F" first="Frédéric" last="Caux">Frédéric Caux</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Hôpital Avicenne, Université Paris 13-Sorbonne Paris Cité, Bobigny</wicri:regionArea><placeName><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author wicri:is="80%"><name sortKey="Abramowicz, Marc" sort="Abramowicz, Marc" uniqKey="Abramowicz M" first="Marc" last="Abramowicz">Marc Abramowicz</name></author><author wicri:is="80%"><name sortKey="Bessis, Didier" sort="Bessis, Didier" uniqKey="Bessis D" first="Didier" last="Bessis">Didier Bessis</name></author><author wicri:is="80%"><name sortKey="Bieth, Eric" sort="Bieth, Eric" uniqKey="Bieth E" first="Eric" last="Bieth">Eric Bieth</name></author><author wicri:is="80%"><name sortKey="Berard, Valerie Bonadonaon" sort="Berard, Valerie Bonadonaon" uniqKey="Berard V" first="Valérie Bonadonaon" last="Bérard">Valérie Bonadonaon Bérard</name></author><author wicri:is="80%"><name sortKey="Bonnetblanc, Jean Marie" sort="Bonnetblanc, Jean Marie" uniqKey="Bonnetblanc J" first="Jean-Marie" last="Bonnetblanc">Jean-Marie Bonnetblanc</name></author><author wicri:is="80%"><name sortKey="Demange, Liliane" sort="Demange, Liliane" uniqKey="Demange L" first="Liliane" last="Demange">Liliane Demange</name></author><author wicri:is="80%"><name sortKey="Feillet, Francois" sort="Feillet, Francois" uniqKey="Feillet F" first="François" last="Feillet">François Feillet</name></author><author wicri:is="80%"><name sortKey="Frebourg, Thierry" sort="Frebourg, Thierry" uniqKey="Frebourg T" first="Thierry" last="Frebourg">Thierry Frebourg</name></author><author wicri:is="80%"><name sortKey="Giraud, Sophie" sort="Giraud, Sophie" uniqKey="Giraud S" first="Sophie" last="Giraud">Sophie Giraud</name></author><author wicri:is="80%"><name sortKey="Giurgea, Irina" sort="Giurgea, Irina" uniqKey="Giurgea I" first="Irina" last="Giurgea">Irina Giurgea</name></author><author wicri:is="80%"><name sortKey="Heron, Delphine" sort="Heron, Delphine" uniqKey="Heron D" first="Delphine" last="Heron">Delphine Heron</name></author><author wicri:is="80%"><name sortKey="Holder, Muriel" sort="Holder, Muriel" uniqKey="Holder M" first="Muriel" last="Holder">Muriel Holder</name></author><author wicri:is="80%"><name sortKey="Journel, Hubert" sort="Journel, Hubert" uniqKey="Journel H" first="Hubert" last="Journel">Hubert Journel</name></author><author wicri:is="80%"><name sortKey="Julia, Sophie" sort="Julia, Sophie" uniqKey="Julia S" first="Sophie" last="Julia">Sophie Julia</name></author><author wicri:is="80%"><name sortKey="Kacem, Maha" sort="Kacem, Maha" uniqKey="Kacem M" first="Maha" last="Kacem">Maha Kacem</name></author><author wicri:is="80%"><name sortKey="Lejeune, Sophie" sort="Lejeune, Sophie" uniqKey="Lejeune S" first="Sophie" last="Lejeune">Sophie Lejeune</name></author><author wicri:is="80%"><name sortKey="Leprat, Frederic" sort="Leprat, Frederic" uniqKey="Leprat F" first="Frédéric" last="Leprat">Frédéric Leprat</name></author><author wicri:is="80%"><name sortKey="Leroux, Dominique" sort="Leroux, Dominique" uniqKey="Leroux D" first="Dominique" last="Leroux">Dominique Leroux</name></author><author wicri:is="80%"><name sortKey="Lok, Catherine" sort="Lok, Catherine" uniqKey="Lok C" first="Catherine" last="Lok">Catherine Lok</name></author><author wicri:is="80%"><name sortKey="Lortholary, Alain" sort="Lortholary, Alain" uniqKey="Lortholary A" first="Alain" last="Lortholary">Alain Lortholary</name></author><author wicri:is="80%"><name sortKey="Lyonnet, Stanislas" sort="Lyonnet, Stanislas" uniqKey="Lyonnet S" first="Stanislas" last="Lyonnet">Stanislas Lyonnet</name></author><author wicri:is="80%"><name sortKey="Margueritte, Genevieve" sort="Margueritte, Genevieve" uniqKey="Margueritte G" first="Geneviève" last="Margueritte">Geneviève Margueritte</name></author><author wicri:is="80%"><name sortKey="Mauillon, Jacques" sort="Mauillon, Jacques" uniqKey="Mauillon J" first="Jacques" last="Mauillon">Jacques Mauillon</name></author><author wicri:is="80%"><name sortKey="Mazereeuw Hautier, Juliette" sort="Mazereeuw Hautier, Juliette" uniqKey="Mazereeuw Hautier J" first="Juliette" last="Mazereeuw-Hautier">Juliette Mazereeuw-Hautier</name></author><author wicri:is="80%"><name sortKey="Odent, Sylvie" sort="Odent, Sylvie" uniqKey="Odent S" first="Sylvie" last="Odent">Sylvie Odent</name></author><author wicri:is="80%"><name sortKey="Penet, Clotilde" sort="Penet, Clotilde" uniqKey="Penet C" first="Clotilde" last="Penet">Clotilde Penet</name></author><author wicri:is="80%"><name sortKey="Philippe, Anne" sort="Philippe, Anne" uniqKey="Philippe A" first="Anne" last="Philippe">Anne Philippe</name></author><author wicri:is="80%"><name sortKey="Plauchu, Henri" sort="Plauchu, Henri" uniqKey="Plauchu H" first="Henri" last="Plauchu">Henri Plauchu</name></author><author wicri:is="80%"><name sortKey="Plessismenceau, Ghislaine" sort="Plessismenceau, Ghislaine" uniqKey="Plessismenceau G" first="Ghislaine" last="Plessismenceau">Ghislaine Plessismenceau</name></author><author wicri:is="80%"><name sortKey="Plouvieron, Emmanuel" sort="Plouvieron, Emmanuel" uniqKey="Plouvieron E" first="Emmanuel" last="Plouvieron">Emmanuel Plouvieron</name></author><author wicri:is="80%"><name sortKey="Richard, Marie Aleth" sort="Richard, Marie Aleth" uniqKey="Richard M" first="Marie-Aleth" last="Richard">Marie-Aleth Richard</name></author><author wicri:is="80%"><name sortKey="Saadi, Abdelkrim" sort="Saadi, Abdelkrim" uniqKey="Saadi A" first="Abdelkrim" last="Saadi">Abdelkrim Saadi</name></author><author wicri:is="80%"><name sortKey="Saurin, Jean Christophe" sort="Saurin, Jean Christophe" uniqKey="Saurin J" first="Jean-Christophe" last="Saurin">Jean-Christophe Saurin</name></author><author wicri:is="80%"><name sortKey="Tinat, Julie" sort="Tinat, Julie" uniqKey="Tinat J" first="Julie" last="Tinat">Julie Tinat</name></author><author wicri:is="80%"><name sortKey="Vabres, Pierre" sort="Vabres, Pierre" uniqKey="Vabres P" first="Pierre" last="Vabres">Pierre Vabres</name></author><author wicri:is="80%"><name sortKey="Van Maldergemteil, Lionel" sort="Van Maldergemteil, Lionel" uniqKey="Van Maldergemteil L" first="Lionel" last="Van Maldergemteil">Lionel Van Maldergemteil</name></author><author wicri:is="80%"><name sortKey="Vennin, Philippe" sort="Vennin, Philippe" uniqKey="Vennin P" first="Philippe" last="Vennin">Philippe Vennin</name></author><author wicri:is="80%"><name sortKey="Weiller, Pierre Jean" sort="Weiller, Pierre Jean" uniqKey="Weiller P" first="Pierre-Jean" last="Weiller">Pierre-Jean Weiller</name></author></analytic><monogr></monogr><series><title level="j">Journal of Medical Genetics</title><title level="j" type="abbrev">J Med Genet</title><idno type="ISSN">0022-2593</idno><idno type="eISSN">1468-6244</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2013-04">2013-04</date><biblScope unit="volume">50</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="255">255</biblScope></imprint><idno type="ISSN">0022-2593</idno></series><idno type="istex">A1DD872E5B674C5BA8B2B7D13472E3D9920DEC5B</idno><idno type="DOI">10.1136/jmedgenet-2012-101339</idno><idno type="href">jmedgenet-50-255.pdf</idno><idno type="ArticleID">jmedgenet-2012-101339</idno><idno type="PMID">23335809</idno><idno type="local">jmedgenet;50/4/255</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-2593</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background PTEN hamartoma tumour syndrome (PHTS) encompasses several clinical syndromes with germline mutations in the PTEN tumour suppressor gene, including Cowden syndrome which is characterised by an increased risk of breast and thyroid cancers. Because PHTS is rare, data regarding cancer risks and genotype–phenotype correlations are limited. The objective of this study was to better define cancer risks in this syndrome with respect to the type and location of PTEN mutations. Methods 154 PHTS individuals with a deleterious germline PTEN mutation were recruited from the activity of the Institut Bergonié genetic laboratory. Detailed phenotypic information was obtained for 146 of them. Age and sex adjusted standardised incidence ratio (SIR) calculations, cumulative cancer risk estimations, and genotype–phenotype analyses were performed. Results Elevated SIRs were found mainly for female breast cancer (39.1, 95% CI 24.8 to 58.6), thyroid cancer in women (43.2, 95% CI 19.7 to 82.1) and in men (199.5, 95% CI 106.39 to 342.03), melanoma in women (28.3, 95% CI 7.6 to 35.4) and in men (39.4, 95% CI 10.6 to 100.9), and endometrial cancer (48.7, 95% CI 9.8 to 142.3). Cumulative cancer risks at age 70 were 85% (95% CI 70% to 95%) for any cancer, 77% (95% CI 59% to 91%) for female breast cancer, and 38% (95% CI 25% to 56%) for thyroid cancer. The risk of cancer was two times greater in women with PHTS than in men with PHTS (p<0.05). Conclusions This study shows a considerably high cumulative risk of cancer for patients with PHTS, mainly in women without clear genotype–phenotype correlation for this cancer risk. New recommendations for the management of PHTS patients are proposed.</div></front></TEI><affiliations><list><country><li>France</li><li>Suisse</li></country><region><li>Aquitaine</li></region><settlement><li>Angers</li><li>Bobigny</li><li>Bordeaux</li><li>Le Havre</li><li>Nantes</li><li>Poitiers</li><li>Rennes</li><li>Strasbourg</li></settlement><orgName><li>Université de Bordeaux</li></orgName></list><tree><noCountry><name sortKey="Abramowicz, Marc" sort="Abramowicz, Marc" uniqKey="Abramowicz M" first="Marc" last="Abramowicz">Marc Abramowicz</name><name sortKey="Berard, Valerie Bonadonaon" sort="Berard, Valerie Bonadonaon" uniqKey="Berard V" first="Valérie Bonadonaon" last="Bérard">Valérie Bonadonaon Bérard</name><name sortKey="Bessis, Didier" sort="Bessis, Didier" uniqKey="Bessis D" first="Didier" last="Bessis">Didier Bessis</name><name sortKey="Bieth, Eric" sort="Bieth, Eric" uniqKey="Bieth E" first="Eric" last="Bieth">Eric Bieth</name><name sortKey="Bonnetblanc, Jean Marie" sort="Bonnetblanc, Jean Marie" uniqKey="Bonnetblanc J" first="Jean-Marie" last="Bonnetblanc">Jean-Marie Bonnetblanc</name><name sortKey="Demange, Liliane" sort="Demange, Liliane" uniqKey="Demange L" first="Liliane" last="Demange">Liliane Demange</name><name sortKey="Feillet, Francois" sort="Feillet, Francois" uniqKey="Feillet F" first="François" last="Feillet">François Feillet</name><name sortKey="Frebourg, Thierry" sort="Frebourg, Thierry" uniqKey="Frebourg T" first="Thierry" last="Frebourg">Thierry Frebourg</name><name sortKey="Giraud, Sophie" sort="Giraud, Sophie" uniqKey="Giraud S" first="Sophie" last="Giraud">Sophie Giraud</name><name sortKey="Giurgea, Irina" sort="Giurgea, Irina" uniqKey="Giurgea I" first="Irina" last="Giurgea">Irina Giurgea</name><name sortKey="Heron, Delphine" sort="Heron, Delphine" uniqKey="Heron D" first="Delphine" last="Heron">Delphine Heron</name><name sortKey="Holder, Muriel" sort="Holder, Muriel" uniqKey="Holder M" first="Muriel" last="Holder">Muriel Holder</name><name sortKey="Journel, Hubert" sort="Journel, Hubert" uniqKey="Journel H" first="Hubert" last="Journel">Hubert Journel</name><name sortKey="Julia, Sophie" sort="Julia, Sophie" uniqKey="Julia S" first="Sophie" last="Julia">Sophie Julia</name><name sortKey="Kacem, Maha" sort="Kacem, Maha" uniqKey="Kacem M" first="Maha" last="Kacem">Maha Kacem</name><name sortKey="Lejeune, Sophie" sort="Lejeune, Sophie" uniqKey="Lejeune S" first="Sophie" last="Lejeune">Sophie Lejeune</name><name sortKey="Leprat, Frederic" sort="Leprat, Frederic" uniqKey="Leprat F" first="Frédéric" last="Leprat">Frédéric Leprat</name><name sortKey="Leroux, Dominique" sort="Leroux, Dominique" uniqKey="Leroux D" first="Dominique" last="Leroux">Dominique Leroux</name><name sortKey="Lok, Catherine" sort="Lok, Catherine" uniqKey="Lok C" first="Catherine" last="Lok">Catherine Lok</name><name sortKey="Lortholary, Alain" sort="Lortholary, Alain" uniqKey="Lortholary A" first="Alain" last="Lortholary">Alain Lortholary</name><name sortKey="Lyonnet, Stanislas" sort="Lyonnet, Stanislas" uniqKey="Lyonnet S" first="Stanislas" last="Lyonnet">Stanislas Lyonnet</name><name sortKey="Margueritte, Genevieve" sort="Margueritte, Genevieve" uniqKey="Margueritte G" first="Geneviève" last="Margueritte">Geneviève Margueritte</name><name sortKey="Mauillon, Jacques" sort="Mauillon, Jacques" uniqKey="Mauillon J" first="Jacques" last="Mauillon">Jacques Mauillon</name><name sortKey="Mazereeuw Hautier, Juliette" sort="Mazereeuw Hautier, Juliette" uniqKey="Mazereeuw Hautier J" first="Juliette" last="Mazereeuw-Hautier">Juliette Mazereeuw-Hautier</name><name sortKey="Odent, Sylvie" sort="Odent, Sylvie" uniqKey="Odent S" first="Sylvie" last="Odent">Sylvie Odent</name><name sortKey="Penet, Clotilde" sort="Penet, Clotilde" uniqKey="Penet C" first="Clotilde" last="Penet">Clotilde Penet</name><name sortKey="Philippe, Anne" sort="Philippe, Anne" uniqKey="Philippe A" first="Anne" last="Philippe">Anne Philippe</name><name sortKey="Plauchu, Henri" sort="Plauchu, Henri" uniqKey="Plauchu H" first="Henri" last="Plauchu">Henri Plauchu</name><name sortKey="Plessismenceau, Ghislaine" sort="Plessismenceau, Ghislaine" uniqKey="Plessismenceau G" first="Ghislaine" last="Plessismenceau">Ghislaine Plessismenceau</name><name sortKey="Plouvieron, Emmanuel" sort="Plouvieron, Emmanuel" uniqKey="Plouvieron E" first="Emmanuel" last="Plouvieron">Emmanuel Plouvieron</name><name sortKey="Richard, Marie Aleth" sort="Richard, Marie Aleth" uniqKey="Richard M" first="Marie-Aleth" last="Richard">Marie-Aleth Richard</name><name sortKey="Saadi, Abdelkrim" sort="Saadi, Abdelkrim" uniqKey="Saadi A" first="Abdelkrim" last="Saadi">Abdelkrim Saadi</name><name sortKey="Saurin, Jean Christophe" sort="Saurin, Jean Christophe" uniqKey="Saurin J" first="Jean-Christophe" last="Saurin">Jean-Christophe Saurin</name><name sortKey="Tinat, Julie" sort="Tinat, Julie" uniqKey="Tinat J" first="Julie" last="Tinat">Julie Tinat</name><name sortKey="Vabres, Pierre" sort="Vabres, Pierre" uniqKey="Vabres P" first="Pierre" last="Vabres">Pierre Vabres</name><name sortKey="Van Maldergemteil, Lionel" sort="Van Maldergemteil, Lionel" uniqKey="Van Maldergemteil L" first="Lionel" last="Van Maldergemteil">Lionel Van Maldergemteil</name><name sortKey="Vennin, Philippe" sort="Vennin, Philippe" uniqKey="Vennin P" first="Philippe" last="Vennin">Philippe Vennin</name><name sortKey="Weiller, Pierre Jean" sort="Weiller, Pierre Jean" uniqKey="Weiller P" first="Pierre-Jean" last="Weiller">Pierre-Jean Weiller</name></noCountry><country name="France"><noRegion><name sortKey="Bubien, Virginie" sort="Bubien, Virginie" uniqKey="Bubien V" first="Virginie" last="Bubien">Virginie Bubien</name></noRegion><name sortKey="Barouk Simonet, Emmanuelle" sort="Barouk Simonet, Emmanuelle" uniqKey="Barouk Simonet E" first="Emmanuelle" last="Barouk-Simonet">Emmanuelle Barouk-Simonet</name><name sortKey="Bonneau, Dominique" sort="Bonneau, Dominique" uniqKey="Bonneau D" first="Dominique" last="Bonneau">Dominique Bonneau</name><name sortKey="Bonnet, Francoise" sort="Bonnet, Francoise" uniqKey="Bonnet F" first="Françoise" last="Bonnet">Françoise Bonnet</name><name sortKey="Bonnet, Francoise" sort="Bonnet, Francoise" uniqKey="Bonnet F" first="Françoise" last="Bonnet">Françoise Bonnet</name><name sortKey="Brouste, Veronique" sort="Brouste, Veronique" uniqKey="Brouste V" first="Veronique" last="Brouste">Veronique Brouste</name><name sortKey="Caron, Olivier" sort="Caron, Olivier" uniqKey="Caron O" first="Olivier" last="Caron">Olivier Caron</name><name sortKey="Caux, Frederic" sort="Caux, Frederic" uniqKey="Caux F" first="Frédéric" last="Caux">Frédéric Caux</name><name sortKey="David, Albert" sort="David, Albert" uniqKey="David A" first="Albert" last="David">Albert David</name><name sortKey="Delnatte, Capucine" sort="Delnatte, Capucine" uniqKey="Delnatte C" first="Capucine" last="Delnatte">Capucine Delnatte</name><name sortKey="Dugast, Catherine" sort="Dugast, Catherine" uniqKey="Dugast C" first="Catherine" last="Dugast">Catherine Dugast</name><name sortKey="Edery, Patrick" sort="Edery, Patrick" uniqKey="Edery P" first="Patrick" last="Edery">Patrick Edery</name><name sortKey="Fricker, Jean Pierre" sort="Fricker, Jean Pierre" uniqKey="Fricker J" first="Jean-Pierre" last="Fricker">Jean-Pierre Fricker</name><name sortKey="Gilbert Dussardier, Brigitte" sort="Gilbert Dussardier, Brigitte" uniqKey="Gilbert Dussardier B" first="Brigitte" last="Gilbert-Dussardier">Brigitte Gilbert-Dussardier</name><name sortKey="Hoppe, Stephanie" sort="Hoppe, Stephanie" uniqKey="Hoppe S" first="Stéphanie" last="Hoppe">Stéphanie Hoppe</name><name sortKey="Layet, Valerie" sort="Layet, Valerie" uniqKey="Layet V" first="Valérie" last="Layet">Valérie Layet</name><name sortKey="Longy, Michel" sort="Longy, Michel" uniqKey="Longy M" first="Michel" last="Longy">Michel Longy</name><name sortKey="Longy, Michel" sort="Longy, Michel" uniqKey="Longy M" first="Michel" last="Longy">Michel Longy</name><name sortKey="Sevenet, Nicolas" sort="Sevenet, Nicolas" uniqKey="Sevenet N" first="Nicolas" last="Sevenet">Nicolas Sevenet</name><name sortKey="Sevenet, Nicolas" sort="Sevenet, Nicolas" uniqKey="Sevenet N" first="Nicolas" last="Sevenet">Nicolas Sevenet</name></country><country name="Suisse"><noRegion><name sortKey="Bottani, Armand" sort="Bottani, Armand" uniqKey="Bottani A" first="Armand" last="Bottani">Armand Bottani</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= High cumulative risks of cancer in patients with PTEN hamartoma tumour syndrome
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